Transcription factors with Perturb-seq knockdown data for LINC02762. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02762 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02762, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:112,024,495–112,025,893 | 265.0 kb | Distal (>10kb) Multiome | 1024 | |
| chr11:112,073,749–112,074,754 | 216.0 kb | Distal (>10kb) Multiome | 828 | |
| chr11:112,086,268–112,087,320 | 203.4 kb | Distal (>10kb) Multiome | 883 | |
| chr11:112,225,928–112,226,959 | 63.7 kb | Distal (>10kb) Multiome | 809 | |
| chr11:112,279,983–112,280,834 | 9.4 kb | Proximal (<10kb) | 347 | |
| chr11:112,289,677–112,290,832 | 47 bp | At TSS Multiome | 568 | |
| chr11:113,240,569–113,241,253 | 950.7 kb | Distal (>10kb) Multiome HiCAR | 76 | |
| chr11:113,273,470–113,274,284 | 983.8 kb | Distal (>10kb) Multiome HiCAR | 55 |
Genomic view of the LINC02762 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.