Transcription factors with Perturb-seq knockdown data for LINC02666. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02666 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02666, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:129,656,086–129,657,969 | 127.7 kb | Distal (>10kb) Multiome | 164 | |
| chr10:129,709,992–129,710,841 | 74.5 kb | Distal (>10kb) Multiome | 112 | |
| chr10:129,889,031–129,889,634 | 104.4 kb | Distal (>10kb) Multiome | 197 | |
| chr10:129,958,664–129,960,120 | 174.3 kb | Distal (>10kb) Multiome | 209 | |
| chr10:129,962,882–129,965,582 | 179.4 kb | Distal (>10kb) Multiome | 391 | |
| chr10:129,966,749–129,967,839 | 182.2 kb | Distal (>10kb) Multiome | 84 | |
| chr10:129,967,889–129,969,505 | 184.1 kb | Distal (>10kb) Multiome | 258 | |
| chr10:129,971,147–129,971,990 | 186.8 kb | Distal (>10kb) Multiome | 290 | |
| chr10:129,985,548–129,985,944 | 200.8 kb | Distal (>10kb) Multiome | 16 |
Genomic view of the LINC02666 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.