Transcription factors with Perturb-seq knockdown data for LINC02623. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02623 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02623, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,864,710–42,864,867 | 6.7 kb | Proximal (<10kb) | 18 | |
| chr10:42,866,108–42,867,222 | 4.3 kb | Proximal (<10kb) | 204 | |
| chr10:42,871,229–42,871,776 | at TSS | At TSS | 52 | |
| chr10:42,871,877–42,872,048 | 357 bp | At TSS | 5 |
Genomic view of the LINC02623 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.