Transcription factors with Perturb-seq knockdown data for LINC02607. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02607 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02607, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:95,233,248–95,234,813 | 276.1 kb | Distal (>10kb) Multiome | 938 | |
| chr1:95,510,041–95,510,637 | at TSS | At TSS | 31 | |
| chr1:95,518,344–95,518,903 | 8.2 kb | Proximal (<10kb) | 28 | |
| chr1:95,742,286–95,743,852 | 232.6 kb | Distal (>10kb) Multiome | 260 | |
| chr1:96,845,384–96,846,141 | 1335.6 kb | Distal (>10kb) Multiome HiCAR | 211 |
Genomic view of the LINC02607 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.