Transcription factors with Perturb-seq knockdown data for LINC02506. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02506 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02506, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:30,716,774–30,723,383 | 1277.0 kb | Distal (>10kb) Multiome HiCAR | 790 | |
| chr4:31,995,117–31,995,533 | 1.8 kb | Proximal (<10kb) | 22 | |
| chr4:31,996,019–31,997,439 | 709 bp | At TSS Multiome | 302 | |
| chr4:32,001,230–32,001,359 | 3.9 kb | Proximal (<10kb) | 26 | |
| chr4:32,003,610–32,004,158 | 6.2 kb | Proximal (<10kb) | 115 |
Genomic view of the LINC02506 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.