Transcription factors with Perturb-seq knockdown data for LINC02454. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02454 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02454, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:65,598,542–65,599,032 | 3.8 kb | Proximal (<10kb) | 12 | |
| chr12:65,602,583–65,602,804 | at TSS | At TSS | 311 | |
| chr12:65,603,012–65,603,339 | 213 bp | At TSS | 214 | |
| chr12:65,603,488–65,603,744 | 689 bp | At TSS | 186 |
Genomic view of the LINC02454 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.