Transcription factors with Perturb-seq knockdown data for LINC02301. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02301 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02301, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:81,561,083–81,562,335 | 1081.1 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr14:81,613,059–81,614,231 | 1029.0 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr14:82,562,472–82,563,328 | 79.6 kb | Distal (>10kb) Multiome | 106 | |
| chr14:82,642,450–82,642,924 | at TSS | At TSS | 138 | |
| chr14:82,646,463–82,646,872 | 3.9 kb | Proximal (<10kb) | 3 | |
| chr14:82,647,019–82,647,879 | 4.4 kb | Proximal (<10kb) | 50 |
Genomic view of the LINC02301 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.