Transcription factors with Perturb-seq knockdown data for LINC02202. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02202 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02202, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:159,094,940–159,095,707 | 4.8 kb | Proximal (<10kb) | 237 | |
| chr5:159,095,813–159,096,967 | 3.5 kb | Proximal (<10kb) | 82 | |
| chr5:159,097,787–159,098,327 | 2.2 kb | Proximal (<10kb) | 160 | |
| chr5:159,099,052–159,099,469 | 1.0 kb | Proximal (<10kb) | 338 | |
| chr5:159,099,838–159,101,146 | at TSS | At TSS | 500 | |
| chr5:159,103,843–159,104,543 | 3.4 kb | Proximal (<10kb) | 104 | |
| chr5:159,105,222–159,105,841 | 4.7 kb | Proximal (<10kb) | 82 | |
| chr5:159,106,607–159,107,108 | 6.1 kb | Proximal (<10kb) | 382 |
Genomic view of the LINC02202 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.