Transcription factors with Perturb-seq knockdown data for LINC01841. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01841 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01841, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,071,936–14,072,417 | 291.8 kb | Distal (>10kb) Multiome | 676 | |
| chr19:14,072,991–14,073,911 | 290.4 kb | Distal (>10kb) Multiome | 589 | |
| chr19:14,081,022–14,082,024 | 282.5 kb | Distal (>10kb) Multiome | 806 | |
| chr19:14,089,535–14,092,049 | 273.0 kb | Distal (>10kb) Multiome | 766 | |
| chr19:14,117,519–14,118,617 | 246.0 kb | Distal (>10kb) Multiome | 734 | |
| chr19:14,136,079–14,137,770 | 227.1 kb | Distal (>10kb) Multiome | 978 | |
| chr19:14,206,623–14,207,699 | 156.7 kb | Distal (>10kb) Multiome | 444 | |
| chr19:14,247,378–14,248,008 | 116.4 kb | Distal (>10kb) Multiome | 109 | |
| chr19:14,248,166–14,249,635 | 115.2 kb | Distal (>10kb) Multiome | 230 | |
| chr19:14,264,813–14,266,130 | 98.4 kb | Distal (>10kb) Multiome | 223 | |
| chr19:14,294,831–14,295,420 | 68.8 kb | Distal (>10kb) Multiome | 60 | |
| chr19:14,363,590–14,364,020 | 284 bp | At TSS Multiome | 402 | |
| chr19:14,366,729–14,366,920 | 2.7 kb | Proximal (<10kb) | 182 | |
| chr19:14,405,442–14,406,893 | 42.2 kb | Distal (>10kb) Multiome | 662 | |
| chr19:14,418,847–14,419,795 | 55.4 kb | Distal (>10kb) Multiome | 817 | |
| chr19:14,432,848–14,433,780 | 69.4 kb | Distal (>10kb) Multiome | 524 | |
| chr19:14,450,232–14,451,000 | 86.6 kb | Distal (>10kb) Multiome | 271 | |
| chr19:14,472,177–14,472,986 | 108.6 kb | Distal (>10kb) Multiome | 566 | |
| chr19:14,495,705–14,496,690 | 132.3 kb | Distal (>10kb) Multiome | 813 | |
| chr19:14,517,523–14,519,160 | 154.6 kb | Distal (>10kb) Multiome | 952 | |
| chr19:14,528,857–14,530,279 | 165.5 kb | Distal (>10kb) Multiome | 842 | |
| chr19:14,536,700–14,537,683 | 173.2 kb | Distal (>10kb) Multiome | 329 | |
| chr19:14,564,060–14,565,155 | 200.5 kb | Distal (>10kb) Multiome | 226 | |
| chr19:14,571,772–14,572,330 | 208.1 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the LINC01841 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.