Transcription factors with Perturb-seq knockdown data for LINC01484. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01484 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01484, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:173,615,977–173,617,113 | 129.6 kb | Distal (>10kb) Multiome | 845 | |
| chr5:173,653,855–173,654,363 | 92.2 kb | Distal (>10kb) Multiome | 34 | |
| chr5:173,753,421–173,753,686 | 7.1 kb | Proximal (<10kb) | 430 | |
| chr5:173,887,593–173,889,015 | 141.8 kb | Distal (>10kb) Multiome | 862 | |
| chr5:173,972,772–173,973,892 | 227.1 kb | Distal (>10kb) Multiome HiCAR | 508 |
Genomic view of the LINC01484 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.