Transcription factors with Perturb-seq knockdown data for LINC01482. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01482 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01482, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:68,291,089–68,292,878 | 300.4 kb | Distal (>10kb) Multiome | 972 | |
| chr17:68,456,319–68,458,376 | 134.1 kb | Distal (>10kb) Multiome | 914 | |
| chr17:68,462,644–68,463,284 | 128.7 kb | Distal (>10kb) Multiome | 394 | |
| chr17:68,511,401–68,513,461 | 79.5 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:68,591,587–68,592,054 | at TSS | At TSS | 95 | |
| chr17:68,599,584–68,601,475 | 8.5 kb | Proximal (<10kb) Multiome | 707 | |
| chr17:68,700,732–68,701,756 | 109.3 kb | Distal (>10kb) Multiome | 188 | |
| chr17:68,732,063–68,732,967 | 140.7 kb | Distal (>10kb) Multiome HiCAR | 284 | |
| chr17:68,777,450–68,779,000 | 186.6 kb | Distal (>10kb) Multiome | 533 |
Genomic view of the LINC01482 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.