Transcription factors with Perturb-seq knockdown data for LINC01431. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01431 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01431, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:23,349,714–23,351,638 | 6.5 kb | Proximal (<10kb) | 1037 | |
| chr20:23,355,682–23,356,065 | 2.0 kb | Proximal (<10kb) | 17 | |
| chr20:23,356,179–23,356,563 | 1.5 kb | Proximal (<10kb) | 95 | |
| chr20:23,357,172–23,358,689 | at TSS | At TSS | 873 | |
| chr20:23,361,395–23,363,116 | 3.3 kb | Proximal (<10kb) | 1092 |
Genomic view of the LINC01431 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.