Transcription factors with Perturb-seq knockdown data for LINC01422. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01422 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01422, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:26,588,940–26,590,564 | 268.5 kb | Distal (>10kb) Multiome | 545 | |
| chr22:26,632,639–26,633,120 | 225.8 kb | Distal (>10kb) Multiome | 225 | |
| chr22:26,644,963–26,645,832 | 213.2 kb | Distal (>10kb) Multiome | 522 | |
| chr22:26,658,631–26,659,207 | 199.7 kb | Distal (>10kb) Multiome | 485 | |
| chr22:26,672,265–26,673,339 | 185.8 kb | Distal (>10kb) Multiome | 604 | |
| chr22:26,837,981–26,838,718 | 20.2 kb | Distal (>10kb) Multiome | 128 | |
| chr22:26,952,631–26,953,712 | 94.6 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the LINC01422 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.