Transcription factors with Perturb-seq knockdown data for LINC01392. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01392 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01392, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:115,225,572–115,226,876 | 4.5 kb | Proximal (<10kb) | 249 | |
| chr7:115,227,141–115,227,337 | 4.0 kb | Proximal (<10kb) | 14 | |
| chr7:115,229,189–115,229,997 | 1.4 kb | Proximal (<10kb) | 120 | |
| chr7:115,230,114–115,230,271 | 1.1 kb | Proximal (<10kb) | 10 | |
| chr7:115,230,853–115,231,443 | at TSS | At TSS | 249 |
Genomic view of the LINC01392 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.