Transcription factors with Perturb-seq knockdown data for LINC01278. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01278 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01278, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:63,350,373–63,351,646 | 209.7 kb | Distal (>10kb) Multiome | 565 | |
| chrX:63,560,600–63,561,237 | 39 bp | At TSS Multiome | 488 | |
| chrX:63,754,432–63,755,735 | 194.2 kb | Distal (>10kb) Multiome | 420 | |
| chrX:63,784,770–63,785,722 | 224.2 kb | Distal (>10kb) Multiome | 148 | |
| chrX:63,847,809–63,848,714 | 287.1 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the LINC01278 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.