Transcription factors with Perturb-seq knockdown data for LINC01126. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01126 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01126, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:43,217,487–43,220,385 | 6.8 kb | Proximal (<10kb) | 1089 | |
| chr2:43,221,095–43,221,491 | 5.7 kb | Proximal (<10kb) | 548 | |
| chr2:43,221,758–43,222,372 | 4.8 kb | Proximal (<10kb) | 730 | |
| chr2:43,224,180–43,228,098 | at TSS | At TSS | 1194 | |
| chr2:43,230,588–43,230,755 | 3.4 kb | Proximal (<10kb) | 46 |
Genomic view of the LINC01126 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.