Transcription factors with Perturb-seq knockdown data for LINC00877. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00877 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00877, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:71,875,256–71,876,589 | 224.4 kb | Distal (>10kb) Multiome | 430 | |
| chr3:71,925,496–71,926,501 | 173.7 kb | Distal (>10kb) Multiome | 136 | |
| chr3:72,017,957–72,018,653 | 81.9 kb | Distal (>10kb) Multiome | 191 | |
| chr3:72,028,296–72,029,097 | 71.2 kb | Distal (>10kb) Multiome | 136 | |
| chr3:72,100,040–72,100,430 | at TSS | At TSS | 94 | |
| chr3:72,100,518–72,101,471 | 798 bp | At TSS Multiome | 426 | |
| chr3:72,144,627–72,145,283 | 44.9 kb | Distal (>10kb) Multiome | 527 | |
| chr3:72,334,933–72,335,840 | 235.3 kb | Distal (>10kb) Multiome | 175 |
Genomic view of the LINC00877 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.