Transcription factors with Perturb-seq knockdown data for LINC00621. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00621 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00621, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:22,813,552–22,814,702 | 101.6 kb | Distal (>10kb) Multiome | 150 | |
| chr13:22,848,526–22,849,113 | 67.0 kb | Distal (>10kb) Multiome | 341 | |
| chr13:22,915,434–22,916,071 | 29 bp | At TSS Multiome | 248 | |
| chr13:22,926,118–22,927,390 | 10.8 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the LINC00621 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.