Transcription factors with Perturb-seq knockdown data for LINC00370. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00370 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00370, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:109,263,823–109,265,675 | 6.5 kb | Proximal (<10kb) | 413 | |
| chr13:109,266,989–109,267,372 | 4.8 kb | Proximal (<10kb) | 1 | |
| chr13:109,267,493–109,268,755 | 3.4 kb | Proximal (<10kb) | 9 | |
| chr13:109,271,665–109,272,402 | at TSS | At TSS | 144 | |
| chr13:109,274,126–109,274,933 | 1.9 kb | Proximal (<10kb) | 274 |
Genomic view of the LINC00370 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.