This gene produces a long non-coding RNA that acts as a negative regulator of cell growth. This transcript may promote differentiation and apoptosis. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for LINC00261. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00261 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00261, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:22,490,294–22,491,441 | 87.5 kb | Distal (>10kb) Multiome | 652 | |
| chr20:22,567,276–22,568,785 | 10.3 kb | Distal (>10kb) Multiome | 145 | |
| chr20:22,571,104–22,572,289 | 7.0 kb | Proximal (<10kb) Multiome | 192 | |
| chr20:22,572,443–22,572,833 | 5.8 kb | Proximal (<10kb) | 32 | |
| chr20:22,574,659–22,577,435 | 3.6 kb | Proximal (<10kb) Multiome | 577 | |
| chr20:22,577,666–22,580,215 | 755 bp | At TSS Multiome | 716 | |
| chr20:22,581,831–22,585,678 | 6.2 kb | Proximal (<10kb) Multiome | 872 | |
| chr20:22,585,993–22,587,411 | 8.4 kb | Proximal (<10kb) Multiome | 559 | |
| chr20:22,663,225–22,664,137 | 85.1 kb | Distal (>10kb) Multiome | 211 | |
| chr20:23,349,714–23,351,638 | 772.0 kb | Distal (>10kb) Multiome HiCAR | 1037 | |
| chr20:23,357,172–23,358,689 | 779.7 kb | Distal (>10kb) Multiome HiCAR | 873 |
Genomic view of the LINC00261 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.