The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for LIN7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIN7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIN7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:80,683,932–80,684,590 | 253.6 kb | Distal (>10kb) Multiome | 126 | |
| chr12:80,707,848–80,709,099 | 229.6 kb | Distal (>10kb) Multiome | 237 | |
| chr12:80,775,630–80,776,322 | 162.0 kb | Distal (>10kb) Multiome | 99 | |
| chr12:80,936,276–80,938,142 | 898 bp | At TSS Multiome | 739 | |
| chr12:81,076,350–81,079,144 | 139.8 kb | Distal (>10kb) Multiome | 720 |
Genomic view of the LIN7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.