This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LHFPL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHFPL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHFPL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:35,522,668–35,523,295 | 282.4 kb | Distal (>10kb) Multiome | 419 | |
| chr6:35,687,984–35,689,594 | 116.3 kb | Distal (>10kb) Multiome | 968 | |
| chr6:35,727,435–35,728,457 | 77.4 kb | Distal (>10kb) Multiome | 812 | |
| chr6:35,731,025–35,732,630 | 73.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:35,764,004–35,765,052 | 40.8 kb | Distal (>10kb) Multiome | 254 | |
| chr6:35,776,412–35,776,992 | 28.7 kb | Distal (>10kb) Multiome | 410 | |
| chr6:35,804,967–35,805,624 | 60 bp | At TSS Multiome | 815 | |
| chr6:35,920,112–35,921,529 | 115.8 kb | Distal (>10kb) Multiome | 965 | |
| chr6:35,931,065–35,931,702 | 126.0 kb | Distal (>10kb) Multiome | 77 | |
| chr6:36,027,295–36,028,609 | 222.4 kb | Distal (>10kb) Multiome | 1031 |
Genomic view of the LHFPL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.