This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for LETMD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LETMD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LETMD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:50,763,385–50,764,948 | 284.1 kb | Distal (>10kb) Multiome | 1004 | |
| chr12:50,842,736–50,843,181 | 205.3 kb | Distal (>10kb) Multiome | 133 | |
| chr12:51,025,646–51,026,823 | 21.9 kb | Distal (>10kb) Multiome | 1016 | |
| chr12:51,047,625–51,048,573 | 176 bp | At TSS Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 35.3 kb | Distal (>10kb) Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 124.7 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 169.8 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 190.7 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 221.7 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 272.6 kb | Distal (>10kb) Multiome | 315 |
Genomic view of the LETMD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.