LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]
Transcription factors with Perturb-seq knockdown data for LEPROT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEPROT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEPROT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:65,147,108–65,150,062 | 272.9 kb | Distal (>10kb) Multiome | 912 | |
| chr1:65,253,859–65,255,712 | 166.2 kb | Distal (>10kb) Multiome | 756 | |
| chr1:65,265,365–65,266,424 | 154.8 kb | Distal (>10kb) Multiome | 602 | |
| chr1:65,308,757–65,310,566 | 110.7 kb | Distal (>10kb) Multiome | 950 | |
| chr1:65,419,304–65,421,455 | 284 bp | At TSS Multiome | 961 | |
| chr1:65,467,350–65,468,066 | 47.0 kb | Distal (>10kb) Multiome | 382 | |
| chr1:65,687,566–65,688,519 | 267.3 kb | Distal (>10kb) Multiome HiCAR | 622 |
Genomic view of the LEPROT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.