LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LEO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,681,155–51,681,883 | 290.3 kb | Distal (>10kb) Multiome | 662 | |
| chr15:51,726,326–51,726,848 | 245.2 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 234.2 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 220.2 kb | Distal (>10kb) Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 142.0 kb | Distal (>10kb) Multiome | 787 | |
| chr15:51,971,175–51,972,397 | 53 bp | At TSS Multiome | 887 | |
| chr15:52,008,542–52,009,373 | 37.2 kb | Distal (>10kb) Multiome | 499 | |
| chr15:52,018,740–52,020,253 | 47.5 kb | Distal (>10kb) Multiome | 1045 | |
| chr15:52,111,990–52,112,768 | 140.6 kb | Distal (>10kb) Multiome | 189 | |
| chr15:52,139,658–52,140,475 | 168.2 kb | Distal (>10kb) Multiome | 400 | |
| chr15:52,179,295–52,180,708 | 208.0 kb | Distal (>10kb) Multiome | 715 | |
| chr15:52,261,434–52,262,154 | 290.1 kb | Distal (>10kb) Multiome | 313 |
Genomic view of the LEO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.