Transcription factors with Perturb-seq knockdown data for LEMD1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEMD1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEMD1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,447,468–205,447,874 | 8.1 kb | Proximal (<10kb) | 135 | |
| chr1:205,448,352–205,449,283 | 6.6 kb | Proximal (<10kb) | 269 | |
| chr1:205,449,573–205,450,965 | 5.0 kb | Proximal (<10kb) | 512 | |
| chr1:205,451,988–205,452,191 | 3.7 kb | Proximal (<10kb) | 40 | |
| chr1:205,454,950–205,455,380 | 547 bp | At TSS | 72 | |
| chr1:205,455,490–205,456,122 | at TSS | At TSS | 94 | |
| chr1:205,456,289–205,457,681 | 361 bp | At TSS | 383 |
Genomic view of the LEMD1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.