Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LEMD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEMD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEMD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,210,792–205,212,030 | 238.3 kb | Distal (>10kb) Multiome | 1103 | |
| chr1:205,227,416–205,228,381 | 222.1 kb | Distal (>10kb) Multiome | 495 | |
| chr1:205,229,263–205,229,745 | 220.3 kb | Distal (>10kb) Multiome | 331 | |
| chr1:205,300,603–205,302,127 | 148.4 kb | Distal (>10kb) Multiome | 660 | |
| chr1:205,313,308–205,314,407 | 135.9 kb | Distal (>10kb) Multiome | 327 | |
| chr1:205,321,242–205,322,079 | 128.2 kb | Distal (>10kb) Multiome | 705 | |
| chr1:205,343,395–205,344,420 | 106.0 kb | Distal (>10kb) Multiome | 395 | |
| chr1:205,430,507–205,431,109 | 19.0 kb | Distal (>10kb) Multiome | 387 | |
| chr1:205,440,982–205,441,976 | 8.7 kb | Proximal (<10kb) Multiome | 341 | |
| chr1:205,444,530–205,445,576 | 4.8 kb | Proximal (<10kb) Multiome | 351 | |
| chr1:205,447,468–205,447,874 | 2.4 kb | Proximal (<10kb) Multiome | 135 | |
| chr1:205,448,352–205,449,283 | 1.2 kb | Proximal (<10kb) Multiome | 269 | |
| chr1:205,449,573–205,450,965 | 267 bp | At TSS Multiome HiCAR | 512 | |
| chr1:205,451,988–205,452,191 | 2.1 kb | Proximal (<10kb) | 40 | |
| chr1:205,454,950–205,455,380 | 5.0 kb | Proximal (<10kb) | 72 | |
| chr1:205,455,490–205,456,122 | 5.6 kb | Proximal (<10kb) | 94 | |
| chr1:205,456,289–205,457,681 | 7.4 kb | Proximal (<10kb) Multiome HiCAR | 383 | |
| chr1:205,485,282–205,485,813 | 35.7 kb | Distal (>10kb) Multiome | 590 | |
| chr1:205,504,221–205,505,625 | 54.7 kb | Distal (>10kb) Multiome | 631 | |
| chr1:205,528,647–205,529,482 | 79.2 kb | Distal (>10kb) Multiome HiCAR | 390 | |
| chr1:205,543,280–205,544,028 | 93.7 kb | Distal (>10kb) Multiome | 371 | |
| chr1:205,591,729–205,592,393 | 142.2 kb | Distal (>10kb) Multiome | 624 | |
| chr1:205,631,034–205,632,587 | 182.0 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:205,679,697–205,680,913 | 230.6 kb | Distal (>10kb) Multiome | 568 | |
| chr1:205,748,908–205,750,848 | 299.6 kb | Distal (>10kb) Multiome | 1074 |
Genomic view of the LEMD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.