Predicted to enable sterol ester esterase activity. Involved in cholesterol homeostasis and intracellular triglyceride homeostasis. Acts upstream of with a positive effect on lipid droplet fusion. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LDAH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LDAH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LDAH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:20,524,538–20,525,515 | 298.2 kb | Distal (>10kb) Multiome | 598 | |
| chr2:20,635,654–20,636,525 | 187.1 kb | Distal (>10kb) Multiome | 590 | |
| chr2:20,642,270–20,642,905 | 180.5 kb | Distal (>10kb) Multiome | 430 | |
| chr2:20,650,354–20,651,898 | 171.9 kb | Distal (>10kb) Multiome | 916 | |
| chr2:20,661,529–20,662,170 | 161.3 kb | Distal (>10kb) Multiome | 410 | |
| chr2:20,665,114–20,668,353 | 156.1 kb | Distal (>10kb) Multiome | 705 | |
| chr2:20,822,123–20,823,451 | 29 bp | At TSS Multiome | 1058 | |
| chr2:20,915,185–20,916,351 | 92.6 kb | Distal (>10kb) Multiome | 119 | |
| chr2:21,042,709–21,044,583 | 220.8 kb | Distal (>10kb) Multiome | 943 | |
| chr2:21,056,136–21,056,704 | 233.4 kb | Distal (>10kb) Multiome | 570 |
Genomic view of the LDAH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.