This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for LCTL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LCTL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LCTL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:66,293,215–66,294,349 | 272.3 kb | Distal (>10kb) Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 209.2 kb | Distal (>10kb) Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 179.2 kb | Distal (>10kb) Multiome | 899 | |
| chr15:66,497,104–66,498,247 | 68.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr15:66,504,543–66,505,655 | 60.9 kb | Distal (>10kb) Multiome | 940 | |
| chr15:66,565,732–66,566,041 | at TSS | At TSS | 100 | |
| chr15:66,567,056–66,567,492 | 1.3 kb | Proximal (<10kb) Multiome | 294 | |
| chr15:66,621,672–66,622,446 | 56.2 kb | Distal (>10kb) Multiome | 271 | |
| chr15:66,670,796–66,671,740 | 105.2 kb | Distal (>10kb) Multiome | 241 | |
| chr15:66,673,331–66,673,903 | 107.7 kb | Distal (>10kb) Multiome | 192 | |
| chr15:66,700,619–66,702,650 | 136.3 kb | Distal (>10kb) Multiome | 844 | |
| chr15:66,773,918–66,774,633 | 208.5 kb | Distal (>10kb) Multiome | 524 | |
| chr15:66,842,072–66,842,664 | 276.7 kb | Distal (>10kb) Multiome | 519 |
Genomic view of the LCTL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.