LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LCMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LCMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LCMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:25,014,631–25,015,917 | 96.4 kb | Distal (>10kb) Multiome | 754 | |
| chr16:25,031,451–25,032,258 | 80.1 kb | Distal (>10kb) Multiome | 704 | |
| chr16:25,066,572–25,067,370 | 44.8 kb | Distal (>10kb) Multiome | 634 | |
| chr16:25,106,579–25,107,386 | 4.7 kb | Proximal (<10kb) Multiome | 887 | |
| chr16:25,111,182–25,112,251 | 90 bp | At TSS Multiome | 808 | |
| chr16:25,148,364–25,149,417 | 37.2 kb | Distal (>10kb) Multiome | 104 | |
| chr16:25,256,955–25,259,314 | 147.4 kb | Distal (>10kb) Multiome | 1186 |
Genomic view of the LCMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.