LATS1

large tumor suppressor kinase 1 | WARTS

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]

Member of: DE-2

Biological processes 53 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)G1/S transition of mitotic cell cycle (GO:0000082)G2/M transition of mitotic cell cycle (GO:0000086)centrosome (GO:0005813)cytoplasm (GO:0005737)cytosol (GO:0005829)glutamatergic synapse (GO:0098978)hippo signaling (GO:0035329)hippo signaling (GO:0035329)hippo signaling (GO:0035329)hippo signaling (GO:0035329)hormone-mediated signaling pathway (GO:0009755)hormone-mediated signaling pathway (GO:0009755)magnesium ion binding (GO:0000287)mammary gland epithelial cell differentiation (GO:0060644)microtubule organizing center (GO:0005815)midbody (GO:0030496)mitotic cell cycle phase transition (GO:0044772)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)negative regulation of protein localization to nucleus (GO:1900181)negative regulation of protein localization to nucleus (GO:1900181)negative regulation of protein localization to nucleus (GO:1900181)nuclear estrogen receptor binding (GO:0030331)nucleus (GO:0005634)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)positive regulation of apoptotic process (GO:0043065)postsynapse (GO:0098794)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of actin filament polymerization (GO:0030833)regulation of intracellular estrogen receptor signaling pathway (GO:0033146)regulation of organ growth (GO:0046620)regulation of postsynaptic density assembly (GO:0099151)regulation of protein-containing complex assembly (GO:0043254)regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)regulation of ubiquitin-dependent protein catabolic process (GO:2000058)sister chromatid segregation (GO:0000819)spindle (GO:0005819)spindle pole (GO:0000922)spindle pole (GO:0000922)spindle pole (GO:0000922)

Expression (TPM)

TFs regulating LATS1 0 TFs

Transcription factors with Perturb-seq knockdown data for LATS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LATS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LATS1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LATS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:149,431,999–149,432,482	285.9 kb	Distal (>10kb) Multiome	527
chr6:149,545,230–149,546,831	171.9 kb	Distal (>10kb) Multiome	1020
chr6:149,565,581–149,567,238	151.9 kb	Distal (>10kb) Multiome	1021
chr6:149,648,112–149,649,264	69.4 kb	Distal (>10kb) Multiome	1051
chr6:149,708,994–149,710,258	8.5 kb	Proximal (<10kb) Multiome	141
chr6:149,717,353–149,718,457	71 bp	At TSS Multiome	1074
chr6:149,746,178–149,746,876	28.4 kb	Distal (>10kb) Multiome	812
chr6:149,749,354–149,750,638	31.6 kb	Distal (>10kb) Multiome	967
chr6:149,845,261–149,846,647	127.7 kb	Distal (>10kb) Multiome	234
chr6:149,863,201–149,865,192	145.2 kb	Distal (>10kb) Multiome	906
chr6:149,922,648–149,923,559	205.1 kb	Distal (>10kb) Multiome	419
chr6:149,925,530–149,926,657	208.2 kb	Distal (>10kb) Multiome	390
chr6:149,941,434–149,942,626	223.8 kb	Distal (>10kb) Multiome	476
chr6:149,963,109–149,964,540	245.7 kb	Distal (>10kb) Multiome	691
chr6:150,004,529–150,006,027	287.2 kb	Distal (>10kb) Multiome	798

Genome Browser

Genomic view of the LATS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.