This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for LASP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LASP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LASP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,572,553–38,573,232 | 296.9 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 265.0 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 263.4 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 260.2 kb | Distal (>10kb) Multiome | 229 | |
| chr17:38,673,658–38,675,315 | 194.9 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 167.5 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 165.9 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 164.5 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 151.1 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 149.6 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 139.6 kb | Distal (>10kb) Multiome | 794 | |
| chr17:38,747,498–38,750,334 | 120.0 kb | Distal (>10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 118.1 kb | Distal (>10kb) Multiome | 986 | |
| chr17:38,789,155–38,789,604 | 80.5 kb | Distal (>10kb) Multiome | 144 | |
| chr17:38,798,912–38,800,293 | 69.9 kb | Distal (>10kb) Multiome | 966 | |
| chr17:38,824,673–38,825,720 | 44.5 kb | Distal (>10kb) Multiome | 978 | |
| chr17:38,853,382–38,854,144 | 16.1 kb | Distal (>10kb) Multiome | 1047 | |
| chr17:38,867,391–38,868,381 | 2.2 kb | Proximal (<10kb) Multiome | 640 | |
| chr17:38,868,990–38,869,138 | 719 bp | At TSS | 350 | |
| chr17:38,869,253–38,871,194 | 45 bp | At TSS Multiome | 1074 | |
| chr17:38,871,560–38,871,768 | 1.7 kb | Proximal (<10kb) | 613 | |
| chr17:38,900,769–38,901,637 | 31.5 kb | Distal (>10kb) Multiome | 370 | |
| chr17:38,967,321–38,967,861 | 97.7 kb | Distal (>10kb) Multiome | 219 | |
| chr17:39,011,896–39,012,455 | 142.3 kb | Distal (>10kb) Multiome | 81 | |
| chr17:39,056,695–39,057,296 | 187.1 kb | Distal (>10kb) Multiome | 468 | |
| chr17:39,152,575–39,154,848 | 284.6 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:39,164,617–39,165,311 | 295.1 kb | Distal (>10kb) Multiome | 371 |
Genomic view of the LASP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.