Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LARGE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARGE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARGE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:45,655,292–45,655,791 | 267.2 kb | Distal (>10kb) Multiome | 271 | |
| chr11:45,664,518–45,666,069 | 257.0 kb | Distal (>10kb) Multiome | 223 | |
| chr11:45,771,302–45,772,261 | 150.6 kb | Distal (>10kb) Multiome | 510 | |
| chr11:45,803,866–45,805,789 | 117.5 kb | Distal (>10kb) Multiome | 806 | |
| chr11:45,847,011–45,848,213 | 75.3 kb | Distal (>10kb) Multiome | 845 | |
| chr11:45,885,234–45,886,606 | 37.0 kb | Distal (>10kb) Multiome | 501 | |
| chr11:45,899,383–45,900,756 | 22.7 kb | Distal (>10kb) Multiome | 534 | |
| chr11:45,917,590–45,918,966 | 3.7 kb | Proximal (<10kb) Multiome | 781 | |
| chr11:45,919,915–45,920,439 | 2.2 kb | Proximal (<10kb) | 55 | |
| chr11:45,921,513–45,923,586 | 213 bp | At TSS Multiome | 624 | |
| chr11:46,120,416–46,122,472 | 198.9 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the LARGE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.