Transcription factors with Perturb-seq knockdown data for LAMTOR5-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMTOR5-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMTOR5-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:110,134,868–110,135,830 | 272.4 kb | Distal (>10kb) Multiome | 133 | |
| chr1:110,150,271–110,151,323 | 257.2 kb | Distal (>10kb) Multiome | 278 | |
| chr1:110,209,629–110,212,414 | 197.7 kb | Distal (>10kb) Multiome | 639 | |
| chr1:110,300,420–110,301,012 | 107.2 kb | Distal (>10kb) Multiome | 100 | |
| chr1:110,312,453–110,313,110 | 95.0 kb | Distal (>10kb) Multiome | 331 | |
| chr1:110,337,715–110,340,405 | 68.7 kb | Distal (>10kb) Multiome | 1136 | |
| chr1:110,407,200–110,408,209 | 125 bp | At TSS Multiome | 1029 | |
| chr1:110,412,567–110,412,837 | 4.9 kb | Proximal (<10kb) | 249 | |
| chr1:110,555,155–110,555,934 | 147.7 kb | Distal (>10kb) Multiome | 301 | |
| chr1:110,605,925–110,607,725 | 198.7 kb | Distal (>10kb) Multiome | 300 | |
| chr1:110,619,278–110,620,032 | 211.7 kb | Distal (>10kb) Multiome | 443 | |
| chr1:110,674,115–110,675,737 | 267.1 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the LAMTOR5-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.