This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for LAMTOR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMTOR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMTOR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:99,644,886–99,645,422 | 249.2 kb | Distal (>10kb) Multiome | 137 | |
| chr4:99,893,878–99,895,182 | 91 bp | At TSS Multiome | 653 | |
| chr4:99,945,763–99,947,717 | 52.3 kb | Distal (>10kb) Multiome | 880 | |
| chr4:99,948,810–99,951,411 | 56.1 kb | Distal (>10kb) Multiome | 994 | |
| chr4:100,093,092–100,094,001 | 199.2 kb | Distal (>10kb) Multiome | 358 | |
| chr4:100,189,399–100,191,698 | 296.0 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the LAMTOR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.