Transcription factors with Perturb-seq knockdown data for LAMP5-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMP5-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMP5-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:9,506,660–9,508,630 | 6.4 kb | Proximal (<10kb) | 202 | |
| chr20:9,508,721–9,509,144 | 5.9 kb | Proximal (<10kb) | 60 | |
| chr20:9,514,065–9,515,184 | at TSS | At TSS | 212 | |
| chr20:9,515,630–9,516,846 | 632 bp | At TSS | 185 | |
| chr20:9,518,649–9,519,132 | 3.7 kb | Proximal (<10kb) | 109 |
Genomic view of the LAMP5-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.