Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LAG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,763,677–6,764,983 | 7.5 kb | Proximal (<10kb) | 570 | |
| chr12:6,765,172–6,767,791 | 4.7 kb | Proximal (<10kb) | 824 | |
| chr12:6,768,329–6,769,331 | 3.2 kb | Proximal (<10kb) | 249 | |
| chr12:6,773,635–6,773,979 | 1.1 kb | Proximal (<10kb) | 91 | |
| chr12:6,778,736–6,779,459 | 6.2 kb | Proximal (<10kb) | 777 |
Genomic view of the LAG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.