This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for LACTB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LACTB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LACTB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,041,931–63,043,171 | 80.0 kb | Distal (>10kb) Multiome | 510 | |
| chr15:63,047,449–63,049,284 | 74.2 kb | Distal (>10kb) Multiome | 977 | |
| chr15:63,052,986–63,053,551 | 69.2 kb | Distal (>10kb) Multiome | 265 | |
| chr15:63,121,504–63,122,682 | 687 bp | At TSS Multiome | 750 | |
| chr15:63,157,102–63,158,166 | 35.0 kb | Distal (>10kb) Multiome | 954 | |
| chr15:63,188,797–63,190,016 | 66.9 kb | Distal (>10kb) Multiome | 573 | |
| chr15:63,277,063–63,278,175 | 154.8 kb | Distal (>10kb) Multiome | 651 | |
| chr15:63,381,566–63,382,221 | 259.3 kb | Distal (>10kb) Multiome | 358 | |
| chr15:63,396,367–63,396,999 | 274.2 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the LACTB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.