Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for L3MBTL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = L3MBTL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of L3MBTL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:6,413,762–6,415,500 | 307 bp | At TSS Multiome | 537 | |
| chr18:6,482,378–6,482,977 | 67.8 kb | Distal (>10kb) Multiome | 341 | |
| chr18:6,561,157–6,562,323 | 146.8 kb | Distal (>10kb) Multiome | 293 | |
| chr18:6,566,061–6,566,935 | 151.7 kb | Distal (>10kb) Multiome | 179 | |
| chr18:6,570,439–6,571,791 | 156.3 kb | Distal (>10kb) Multiome | 173 | |
| chr18:6,605,761–6,607,586 | 191.8 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the L3MBTL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.