The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for L3HYPDH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = L3HYPDH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of L3HYPDH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:59,187,813–59,190,715 | 294.5 kb | Distal (>10kb) Multiome | 930 | |
| chr14:59,266,648–59,267,455 | 217.4 kb | Distal (>10kb) Multiome | 53 | |
| chr14:59,445,381–59,446,068 | 38.7 kb | Distal (>10kb) Multiome | 78 | |
| chr14:59,463,731–59,465,599 | 19.3 kb | Distal (>10kb) Multiome | 584 | |
| chr14:59,476,478–59,476,883 | 7.5 kb | Proximal (<10kb) | 23 | |
| chr14:59,483,421–59,485,055 | 5 bp | At TSS Multiome | 1082 | |
| chr14:59,507,182–59,508,205 | 23.2 kb | Distal (>10kb) Multiome | 206 | |
| chr14:59,576,271–59,577,126 | 92.3 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr14:59,630,298–59,630,972 | 146.2 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the L3HYPDH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.