Enables enzyme activator activity and protein-macromolecule adaptor activity. Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRTCAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRTCAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRTCAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,936,148–154,937,752 | 236.3 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:154,955,571–154,956,925 | 217.1 kb | Distal (>10kb) Multiome | 504 | |
| chr1:154,961,269–154,962,529 | 211.6 kb | Distal (>10kb) Multiome | 985 | |
| chr1:154,970,161–154,971,641 | 202.4 kb | Distal (>10kb) Multiome | 535 | |
| chr1:154,972,362–154,975,914 | 198.7 kb | Distal (>10kb) Multiome | 1085 | |
| chr1:154,982,968–154,983,632 | 190.1 kb | Distal (>10kb) Multiome | 693 | |
| chr1:154,998,961–155,004,423 | 174.0 kb | Distal (>10kb) Multiome | 1210 | |
| chr1:155,017,084–155,017,941 | 155.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:155,050,292–155,052,078 | 122.1 kb | Distal (>10kb) Multiome | 948 | |
| chr1:155,061,415–155,064,552 | 109.4 kb | Distal (>10kb) Multiome | 860 | |
| chr1:155,070,748–155,071,423 | 102.2 kb | Distal (>10kb) Multiome HiCAR | 542 | |
| chr1:155,078,524–155,079,535 | 94.5 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr1:155,079,852–155,081,529 | 92.4 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr1:155,084,373–155,086,501 | 88.3 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr1:155,091,315–155,091,900 | 81.7 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr1:155,126,247–155,126,903 | 46.8 kb | Distal (>10kb) Multiome | 776 | |
| chr1:155,127,607–155,128,120 | 45.4 kb | Distal (>10kb) Multiome | 578 | |
| chr1:155,135,100–155,136,750 | 37.5 kb | Distal (>10kb) Multiome | 938 | |
| chr1:155,166,847–155,168,170 | 5.5 kb | Proximal (<10kb) Multiome | 622 | |
| chr1:155,172,629–155,174,979 | 10 bp | At TSS Multiome | 903 | |
| chr1:155,176,698–155,176,895 | 3.4 kb | Proximal (<10kb) | 236 | |
| chr1:155,192,921–155,194,099 | 20.3 kb | Distal (>10kb) Multiome | 755 | |
| chr1:155,194,230–155,195,403 | 21.6 kb | Distal (>10kb) Multiome | 753 | |
| chr1:155,196,127–155,196,592 | 23.1 kb | Distal (>10kb) Multiome | 97 | |
| chr1:155,207,822–155,209,789 | 35.7 kb | Distal (>10kb) Multiome | 826 | |
| chr1:155,226,522–155,227,197 | 53.3 kb | Distal (>10kb) Multiome | 600 | |
| chr1:155,227,312–155,228,116 | 54.3 kb | Distal (>10kb) Multiome | 688 | |
| chr1:155,244,103–155,245,349 | 71.5 kb | Distal (>10kb) Multiome | 900 | |
| chr1:155,250,356–155,251,199 | 77.5 kb | Distal (>10kb) Multiome | 605 | |
| chr1:155,255,032–155,255,921 | 82.2 kb | Distal (>10kb) Multiome | 661 | |
| chr1:155,261,679–155,262,788 | 89.1 kb | Distal (>10kb) Multiome | 921 | |
| chr1:155,272,928–155,274,098 | 100.2 kb | Distal (>10kb) Multiome | 768 | |
| chr1:155,276,933–155,278,884 | 105.2 kb | Distal (>10kb) Multiome | 749 | |
| chr1:155,308,291–155,309,348 | 135.4 kb | Distal (>10kb) Multiome | 934 | |
| chr1:155,320,564–155,321,470 | 147.6 kb | Distal (>10kb) Multiome | 341 | |
| chr1:155,322,680–155,325,643 | 151.0 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the KRTCAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.