Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRTAP5-11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRTAP5-11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRTAP5-11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,447,762–71,449,172 | 154.9 kb | Distal (>10kb) Multiome | 802 | |
| chr11:71,452,706–71,453,785 | 150.2 kb | Distal (>10kb) Multiome | 636 | |
| chr11:71,487,897–71,488,597 | 115.1 kb | Distal (>10kb) Multiome | 181 | |
| chr11:71,607,766–71,608,303 | 4.4 kb | Proximal (<10kb) | 13 | |
| chr11:71,750,971–71,751,686 | 147.9 kb | Distal (>10kb) Multiome | 86 | |
| chr11:71,786,388–71,787,283 | 183.7 kb | Distal (>10kb) Multiome | 289 |
Genomic view of the KRTAP5-11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.