The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KRT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,951,120–51,952,143 | 281.1 kb | Distal (>10kb) Multiome | 587 | |
| chr12:52,005,871–52,007,901 | 225.9 kb | Distal (>10kb) Multiome | 293 | |
| chr12:52,010,041–52,010,749 | 222.3 kb | Distal (>10kb) Multiome | 443 | |
| chr12:52,014,577–52,015,139 | 217.7 kb | Distal (>10kb) Multiome | 72 | |
| chr12:52,022,754–52,024,212 | 208.9 kb | Distal (>10kb) Multiome | 630 | |
| chr12:52,025,442–52,026,162 | 206.9 kb | Distal (>10kb) Multiome | 629 | |
| chr12:52,032,739–52,033,401 | 199.5 kb | Distal (>10kb) Multiome | 640 | |
| chr12:52,036,744–52,037,531 | 195.5 kb | Distal (>10kb) Multiome | 625 | |
| chr12:52,050,161–52,052,728 | 181.4 kb | Distal (>10kb) Multiome | 861 | |
| chr12:52,069,275–52,070,473 | 162.9 kb | Distal (>10kb) Multiome | 901 | |
| chr12:52,119,893–52,120,359 | 112.5 kb | Distal (>10kb) Multiome | 380 | |
| chr12:52,163,813–52,164,287 | 68.5 kb | Distal (>10kb) Multiome | 450 | |
| chr12:52,232,988–52,233,518 | 456 bp | At TSS Multiome | 170 | |
| chr12:52,308,190–52,308,768 | 75.9 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the KRT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.