KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KRT18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRT18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRT18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:52,714,144–52,714,803 | 234.7 kb | Distal (>10kb) Multiome | 145 | |
| chr12:52,879,361–52,880,433 | 69.3 kb | Distal (>10kb) Multiome | 702 | |
| chr12:52,884,158–52,885,336 | 64.3 kb | Distal (>10kb) Multiome | 610 | |
| chr12:52,903,331–52,905,680 | 45.4 kb | Distal (>10kb) Multiome HiCAR | 985 | |
| chr12:52,906,476–52,907,649 | 41.9 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr12:52,945,414–52,946,146 | 3.4 kb | Proximal (<10kb) Multiome | 514 | |
| chr12:52,947,826–52,948,366 | 750 bp | At TSS | 114 | |
| chr12:52,948,516–52,950,156 | 150 bp | At TSS Multiome | 923 | |
| chr12:52,957,069–52,957,367 | 8.0 kb | Proximal (<10kb) | 109 | |
| chr12:53,005,438–53,007,356 | 57.2 kb | Distal (>10kb) Multiome | 995 | |
| chr12:53,046,385–53,049,295 | 98.3 kb | Distal (>10kb) Multiome | 793 | |
| chr12:53,049,465–53,050,530 | 100.8 kb | Distal (>10kb) Multiome | 565 | |
| chr12:53,053,508–53,054,860 | 105.3 kb | Distal (>10kb) Multiome | 646 | |
| chr12:53,078,790–53,079,991 | 130.3 kb | Distal (>10kb) Multiome | 835 | |
| chr12:53,097,544–53,098,160 | 148.6 kb | Distal (>10kb) Multiome | 515 | |
| chr12:53,174,900–53,175,484 | 226.1 kb | Distal (>10kb) Multiome | 474 | |
| chr12:53,179,987–53,181,456 | 231.6 kb | Distal (>10kb) Multiome | 930 | |
| chr12:53,219,787–53,222,151 | 272.0 kb | Distal (>10kb) Multiome | 828 | |
| chr12:53,231,703–53,233,098 | 283.2 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the KRT18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.