Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRT10-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRT10-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRT10-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,615,478–40,615,916 | 203.4 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr17:40,637,853–40,638,362 | 181.0 kb | Distal (>10kb) Multiome | 83 | |
| chr17:40,735,202–40,736,205 | 83.5 kb | Distal (>10kb) Multiome | 21 | |
| chr17:40,818,771–40,819,228 | at TSS | At TSS | 513 | |
| chr17:41,527,111–41,529,407 | 709.3 kb | Distal (>10kb) Multiome HiCAR | 635 | |
| chr17:41,529,883–41,531,145 | 711.3 kb | Distal (>10kb) Multiome HiCAR | 504 | |
| chr17:41,548,740–41,549,518 | 730.0 kb | Distal (>10kb) Multiome HiCAR | 698 | |
| chr17:41,647,765–41,648,495 | 828.9 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr17:41,662,549–41,663,015 | 843.7 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr17:41,665,564–41,667,291 | 848.1 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr17:41,688,103–41,690,064 | 869.7 kb | Distal (>10kb) Multiome HiCAR | 1236 |
Genomic view of the KRT10-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.