Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome; intercellular bridge; and nuclear lumen. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:75,329,660–75,330,647 | 181.4 kb | Distal (>10kb) Multiome | 840 | |
| chr12:75,333,989–75,335,193 | 177.1 kb | Distal (>10kb) Multiome | 460 | |
| chr12:75,390,488–75,391,621 | 120.5 kb | Distal (>10kb) Multiome | 653 | |
| chr12:75,484,124–75,485,111 | 27.0 kb | Distal (>10kb) Multiome | 121 | |
| chr12:75,511,106–75,512,100 | 83 bp | At TSS Multiome | 945 | |
| chr12:75,779,687–75,780,741 | 268.7 kb | Distal (>10kb) Multiome | 288 | |
| chr12:76,029,985–76,033,119 | 520.0 kb | Distal (>10kb) Multiome HiCAR | 1086 | |
| chr12:76,347,962–76,348,990 | 836.8 kb | Distal (>10kb) Multiome HiCAR | 838 | |
| chr12:76,371,854–76,372,495 | 860.6 kb | Distal (>10kb) Multiome HiCAR | 65 | |
| chr12:76,558,693–76,560,264 | 1048.2 kb | Distal (>10kb) Multiome HiCAR | 1006 |
Genomic view of the KRR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.