Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRBOX5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRBOX5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRBOX5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:31,442,550–31,443,636 | 270.2 kb | Distal (>10kb) Multiome | 838 | |
| chr16:31,457,952–31,460,456 | 255.2 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:31,471,780–31,473,168 | 240.4 kb | Distal (>10kb) Multiome HiCAR | 425 | |
| chr16:31,476,391–31,478,207 | 235.5 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr16:31,487,298–31,488,862 | 225.4 kb | Distal (>10kb) Multiome | 323 | |
| chr16:31,507,726–31,508,748 | 204.9 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr16:31,529,299–31,530,211 | 183.6 kb | Distal (>10kb) Multiome | 114 | |
| chr16:31,700,204–31,701,065 | 12.7 kb | Distal (>10kb) Multiome | 787 | |
| chr16:31,709,895–31,710,123 | 3.1 kb | Proximal (<10kb) | 8 | |
| chr16:31,712,839–31,714,180 | 9 bp | At TSS Multiome | 930 | |
| chr16:31,714,369–31,714,866 | 1.1 kb | Proximal (<10kb) | 144 | |
| chr16:31,873,239–31,874,541 | 160.6 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the KRBOX5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.