Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KNSTRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KNSTRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KNSTRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,108,639–40,109,491 | 273.9 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,160,791–40,161,326 | 222.0 kb | Distal (>10kb) Multiome | 762 | |
| chr15:40,323,099–40,324,127 | 59.5 kb | Distal (>10kb) Multiome | 737 | |
| chr15:40,357,707–40,358,772 | 24.8 kb | Distal (>10kb) Multiome | 515 | |
| chr15:40,367,875–40,368,398 | 14.8 kb | Distal (>10kb) Multiome | 846 | |
| chr15:40,382,707–40,383,035 | at TSS | At TSS | 660 | |
| chr15:40,405,523–40,406,103 | 22.8 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 57.9 kb | Distal (>10kb) Multiome | 440 | |
| chr15:40,470,654–40,471,315 | 88.0 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 128.8 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,593,777–40,594,776 | 211.1 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the KNSTRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.