The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for KNDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KNDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KNDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:132,961,992–132,962,618 | 197.9 kb | Distal (>10kb) Multiome | 155 | |
| chr10:133,002,731–133,003,410 | 157.2 kb | Distal (>10kb) Multiome | 78 | |
| chr10:133,087,734–133,088,838 | 72.2 kb | Distal (>10kb) Multiome | 273 | |
| chr10:133,143,227–133,144,444 | 16.2 kb | Distal (>10kb) Multiome | 346 | |
| chr10:133,151,583–133,151,983 | 8.2 kb | Proximal (<10kb) | 70 | |
| chr10:133,159,602–133,160,521 | 23 bp | At TSS Multiome | 198 | |
| chr10:133,229,278–133,231,486 | 70.0 kb | Distal (>10kb) Multiome | 253 | |
| chr10:133,231,897–133,232,673 | 72.1 kb | Distal (>10kb) Multiome | 75 | |
| chr10:133,235,225–133,235,826 | 75.5 kb | Distal (>10kb) Multiome | 122 | |
| chr10:133,236,052–133,238,686 | 77.5 kb | Distal (>10kb) Multiome | 361 | |
| chr10:133,245,223–133,246,111 | 85.6 kb | Distal (>10kb) Multiome | 265 | |
| chr10:133,247,041–133,247,539 | 87.0 kb | Distal (>10kb) Multiome | 168 | |
| chr10:133,257,420–133,258,249 | 97.6 kb | Distal (>10kb) Multiome | 384 | |
| chr10:133,261,265–133,262,426 | 101.8 kb | Distal (>10kb) Multiome | 421 | |
| chr10:133,276,420–133,277,460 | 116.7 kb | Distal (>10kb) Multiome | 216 | |
| chr10:133,307,807–133,309,623 | 148.9 kb | Distal (>10kb) Multiome | 785 | |
| chr10:133,318,523–133,319,017 | 158.6 kb | Distal (>10kb) Multiome | 567 | |
| chr10:133,324,203–133,325,065 | 164.3 kb | Distal (>10kb) Multiome | 243 | |
| chr10:133,329,452–133,330,224 | 169.7 kb | Distal (>10kb) Multiome | 471 | |
| chr10:133,357,077–133,358,582 | 197.7 kb | Distal (>10kb) Multiome | 649 | |
| chr10:133,373,095–133,373,842 | 213.2 kb | Distal (>10kb) Multiome | 589 | |
| chr10:133,377,993–133,380,099 | 219.0 kb | Distal (>10kb) Multiome | 714 | |
| chr10:133,393,908–133,394,705 | 233.9 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the KNDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.