KMT5C

lysine methyltransferase 5C | MGC2705, SUV420H2

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

Developmental clusters: GC7

Biological processes 27 terms

DNA repair (GO:0006281)DNA repair (GO:0006281)S-adenosyl-L-methionine binding (GO:1904047)chromatin binding (GO:0003682)chromatin binding (GO:0003682)chromatin remodeling (GO:0006338)chromosome (GO:0005694)condensed chromosome, centromeric region (GO:0000779)heterochromatin (GO:0000792)histone H4 methyltransferase activity (GO:0140939)histone H4K20 methyltransferase activity (GO:0042799)histone H4K20 methyltransferase activity (GO:0042799)histone H4K20 methyltransferase activity (GO:0042799)histone H4K20 methyltransferase activity (GO:0042799)histone H4K20 monomethyltransferase activity (GO:0140944)histone H4K20me methyltransferase activity (GO:0140941)histone binding (GO:0042393)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)pericentric heterochromatin (GO:0005721)positive regulation of double-strand break repair via nonhomologous end joining (GO:2001034)positive regulation of double-strand break repair via nonhomologous end joining (GO:2001034)positive regulation of isotype switching (GO:0045830)positive regulation of isotype switching (GO:0045830)protein binding (GO:0005515)

Expression (TPM)

TFs regulating KMT5C 0 TFs

Transcription factors with Perturb-seq knockdown data for KMT5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KMT5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KMT5C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KMT5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:55,062,536–55,063,406	276.7 kb	Distal (>10kb) Multiome	586
chr19:55,069,129–55,069,807	270.4 kb	Distal (>10kb) Multiome	288
chr19:55,080,038–55,082,744	258.3 kb	Distal (>10kb) Multiome	639
chr19:55,086,246–55,087,525	252.7 kb	Distal (>10kb) Multiome	258
chr19:55,091,780–55,093,292	247.6 kb	Distal (>10kb) Multiome	208
chr19:55,095,398–55,095,977	244.0 kb	Distal (>10kb) Multiome	90
chr19:55,117,134–55,119,109	222.1 kb	Distal (>10kb) Multiome	881
chr19:55,146,210–55,148,117	192.9 kb	Distal (>10kb) Multiome	528
chr19:55,156,193–55,157,266	183.2 kb	Distal (>10kb) Multiome	317
chr19:55,160,567–55,161,360	179.1 kb	Distal (>10kb) Multiome	554
chr19:55,165,952–55,167,256	173.2 kb	Distal (>10kb) Multiome	719
chr19:55,173,717–55,174,287	165.8 kb	Distal (>10kb) Multiome	330
chr19:55,178,876–55,179,477	160.8 kb	Distal (>10kb) Multiome	479
chr19:55,216,490–55,217,227	123.0 kb	Distal (>10kb) Multiome	1077
chr19:55,257,751–55,259,635	80.7 kb	Distal (>10kb) Multiome	1054
chr19:55,279,599–55,280,933	59.6 kb	Distal (>10kb) Multiome	805
chr19:55,283,835–55,284,716	55.8 kb	Distal (>10kb) Multiome	242
chr19:55,301,640–55,302,240	37.9 kb	Distal (>10kb) Multiome	448
chr19:55,338,676–55,340,358	303 bp	At TSS Multiome	882
chr19:55,340,675–55,341,535	1.5 kb	Proximal (<10kb) Multiome	368
chr19:55,353,720–55,354,487	14.2 kb	Distal (>10kb) Multiome	297
chr19:55,369,099–55,370,447	30.2 kb	Distal (>10kb) Multiome	383
chr19:55,383,539–55,384,553	44.0 kb	Distal (>10kb) Multiome	374
chr19:55,384,697–55,386,560	45.8 kb	Distal (>10kb) Multiome	903
chr19:55,406,950–55,408,675	68.2 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	113.2 kb	Distal (>10kb) Multiome	339
chr19:55,460,784–55,462,230	121.9 kb	Distal (>10kb) Multiome	947
chr19:55,476,048–55,477,307	136.8 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	145.3 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	164.2 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	177.2 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	197.3 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	210.2 kb	Distal (>10kb) Multiome	396
chr19:55,580,080–55,581,090	240.9 kb	Distal (>10kb) Multiome	718
chr19:55,585,644–55,586,314	246.0 kb	Distal (>10kb) Multiome	370
chr19:55,586,698–55,587,594	247.5 kb	Distal (>10kb) Multiome	463
chr19:55,598,551–55,600,991	260.5 kb	Distal (>10kb) Multiome	1018
chr19:55,604,520–55,606,690	265.5 kb	Distal (>10kb) Multiome	820
chr19:55,623,637–55,625,055	284.6 kb	Distal (>10kb) Multiome	650

Genome Browser

Genomic view of the KMT5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.